Developing a range of products to modify the human
microbiome and bring specific health benefits


LPLDL® is a naturally-occurring strain of the bacterial species Lactobacillus plantarum. Lactobacilli are common components of the human intestine and used by the food industry as probiotics for general health benefits.

LPLDL® is unique in that it was selected using OptiBiotix's Optiscreen platform from a collection of over 4,000 candidates for its outstanding capacity to hydrolyse bile salts. This activity is crucial for both bacterial survival in the gut and its use to prevent and manage a number of health conditions such as high cholesterol, high blood pressure, glucose and energy regulation, vitamin metabolism, and liver function.

This creates the potential to use LPLDL® inside multiple products and application areas across both consumer and pharmaceutical health care.

Human volunteer study on high cholesterol levels in humans:

A randomised, controlled human study with LPLDL® was performed by OptiBiotix and the University of Reading (UK) with 50 hypercholesterolemic subjects. LPLDL® showed to:

  • Be completely safe and well tolerated
  • Lower total cholesterol by up to 36.7%
  • Lower LDL cholesterol by up to 13.9%
  • Increase HDL cholesterol by up to 6.5%
  • Lower systolic blood pressure by 5.1%



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