microbiome

Developing a range of products to modify the human
microbiome and bring specific health benefits

Technology Platform : OptiScreen®

OptiScreen® is a proprietary high throughput screening and optimisation technology platform designed to identify microbes within the human microbiome with metabolic pathways which can interact with human physiological processes and bring health benefits

The first application of this platform has been in cholesterol reduction. Following initial work to identify a target mechanism, a successful 'human volunteer study ' trial was completed in 2015 working with the University of Reading in the UK, globally recognised as leaders in this field.

First Product: Cholesterol Reduction

  • Based on an established mechanism, bile salt hydrolysis, more than 4000 strains were screened for activity
  • Three Lactobacillus strains demonstrated in vitro efficacy of between 72 and 81%
  • Human volunteer studies demonstrated 0.1g of product gave reductions in total cholesterol, LDL cholesterol, and blood pressure greater than 1.5 - 2.4 g/d plant sterols/stanols
  • Further work on manufacturing scale up and stability has confirmed low cost high volume manufacture and commercial potential
Cholesterol Reduction

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